Research Articles
1. Amarzguioui M. Holen T. Babaie E. Prydz H., 2003. Tolerance for mutations and chemical modifications in siRNA. Nucleic Acids Research, Vol 31, Issue 2, pp 589-595.
2. Chiu Y. Rana T M., 2003. siRNA function in RNAi: A chemical modification analysis. RNA, Vol 10, Issue 9, pp 1034-1048.
3. Vargason J M. Szittya G. Burgyan J. Hall T., 2003. Size selective recognition of siRNA by an RNA silencing suppressor. Cell, Vol 115, Issue 7, pp 799-811.
4. Casanotto D. Li H. Rossi J., 2002. Functional siRNA expression from transfected PCR products. RNA, Volume 8, pp 1454-1460.
5. Reynolds A. Leake D. Boese Q., Scaringe S., Marshall W. Anastasia K., 2004. Rational siRNA design for RNA interference. Nature Biotechnology, Vol 22, pp 326-330.
6. Tang G., 2004. siRNA and miRNA : an insight into RISCs. Trends in Biochemical Sciences, Vol 30, Issue 2, pp 106-114.
7. Matzke M. Birchler J., 2005. RNAi mediated pathways in the nucleus. Nature Reviews Genetics, Vol 6, pp 24-35.
8. Schiffelers R M et al., 2004. Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle. Nucleic Acids Research, Vol 32, Issue 19, p 149.
9. Medarova Z. Pham W, Farrar C, Petkova V. Moore A, 2007. In vivo imagind of siRNA delivery and silencing in tumors. Nature Medicine, Vol 13, pp 372-377.
10. Ui-Tei K. Naita Y et al., 2004. Guidelines for the selection of highly effective siRNA equences for mammalian and chick RNA interference. Nucleic Aciss Research, Vol 32, Issue 3, pp 936-948.
11. Lipardi C, Wei Q. Paterson B., 2001. RNAi as random degeneration PCR: siRNA primers convert mRNA into dsRNA that are drgraded to generate new siRNAs. Cell, Vol 103, Issue 2, pp 297-307.
12. Klein U, Werth S, Abuharbeid S. Czubayko F. Aigner A, 2005. RNAi mediated gene-targeting through systemic application of polyethyleneimine-complexed siRANA in vivo. Gene Therapy, Vol 12, pp 461-466.
13. Jackson A L. Burchard J. et al., 2006. Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity. RNA, vol 12, pp 1179-1187.
14. Tomari Y et al., 2004. A protein sensor for siRNA symmetry. Science, Vol 306, pp 1377-1380.
15. Szittya G et al., 2003. Low temperature inhibits RNA-silencing-mediated defernce by control of siRNA generation. The EMBO Journal, Vol 22, pp 633-640.
16. Matsukura S. Jones P A. Takai D, 2003. Establishment of conditional vectors for hairpin siRNA knockdowns. Nucleic Acids Research, Volume 31, issue 15, p 77.
17. Kennedy S. Wang D. Ruvkun G, 2004. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature, Vol 427, pp 645-649.
18. Elmen J et al, 2005. Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality. Nucleic Acids Research, Volume 33, Issue 1, pp 439-447.
19. Judge A. Bola G. Lee A. MacLachlan I., 2006. Design of non-inflammotory synthetic siRNA mediating potent gene silencing in vivo. Molecular Theraoy, Volume 13, pp 494-505.
20. Reynolds A et al., 2006. Induction of the interferon response by siRNA is cell type-and duplex-strenght dependent. RNA, volume 12, pp 988-993/
21. Dorn G et al., 2004. siRNA relieves chronic neuropathic pain. Nucleic Acids Research, Vol 32, Issue 5, pp 49.
22. Bitko V. Musiyenko A. Shulyayeva O., Barik S., 2004. Inihibition of respirotary viruses by nasally administered siRNA. Nature Medicine, vol 11, pp 50-55.
23. Judge A et al., 2005. Sequence-dependent stimulation of mammalian inntate immune respose by synthetic siRNA. Nature Biotechnology, Vol 23, pp 457-462.
24. Barlett D. Su H., Hildebrandt I., Weber W., Davis M., 2007. Impact of tumor-specific targeting on biodistribution and afficace of siRNA nanoparticles measured by multimodality in vivo imaging. PNAS, Vol 104. No 39, pp 15549-15554.
25. Butz K et al., 2003. siRNA targeting of the viral E6 oncogene efficiently kills HPV-positive cancer cells. Oncogene, Volume 22, pp 5936-5945.
26. Uchida H. et al., 2004. Adenovirus-mediated transfer of siRNA against Survivin induced apoptosis and attenuated tumor cell growin in vitro and in vivo. Molecular Theraoy, Volume 10, pp 162-171.
27. Li B et al, 2005. Using siRNA in prophylactic and therapeutic reginems against SARC coronavirus in Rhesus macaque. Nature Medicine, vol 11, pp 944-951.
28. Howard K et al., 2006. RNA interference in vitro and in vivo using a chitosan/siRNA nanoparticle system. Molecular Therapy, Volume 14, pp 476-484.
29. Devroe E. Silver P, 2002. Retrovirus-deliverd siRNA. BMC Biotechnology, Vol 2, p 15.
30. Shen C., Buck A., Liu X., Winkler M., Reske S, 2003. Gene silencing by adenovirus-delivered siRNA. FEBS Letters, Volume 539, Issue 1, pp 111-114.
31. Simeoni F. Morris M., Heitz F., Divita G., 2003. Insight into the mechanism of the peptide-based gene delivery system MPG: implications for delivery of siRNA into mammalian cells. Nucleic Acids Research, Vol 31, Issue 11, pp 2717-2724.
32. Kam N, Liu Z., Dai H., 2005. Functionalization of cabon nanotubes via cleavable disulphide bonds for efficient intracellular delivery of siRNA and potenet gene silenceing. Journal of the American Chemical Society, Vol 127, Issue 36, pp 12492-12493.
33. Muratovska A., Eccles M., 2004. Conjugate for effiecient delivery of short interfering RNA (siRNA) into mammalian cells. FEBS Letters, VOl 558, Issue 1, pp 63-68.
34. Behlke M., 2006. Progress towards in vivo use of siRNAs. Molecular Therapy, Vol 13, pp 644-670.
35. McNamara J et al., 2006. Cell-type specific delivery systems of siRNAs with aptamer-siRNA chimeras. Nature Biotechnology, Vol 34, pp 1005-1015.
36. Dassie J P et al., 2009. Systemic administration of optimized aptamer-siRNA chimeras promotes regression of PSMA-expressing tumors. Nature Biotechnology, Volu 27, pp 839-846.
37. Fire A et al., 1998. Potent and specific genetic interference by double-stranded RNA in C. elegans. Nature, Vol 391, Issue 6660, pp 806-811.
38. Mello C, Return to the RNAi World: Rethinking Gene Expression and Evolution. Nobel Lectures, Dec 12, 2006.
39. Fire A, Gene Silencing by Double-stranded RNA, Nobel Lectures, Dec 12, 2006.
41. Wheeler D B et al., Cell Microarrays and RNA Interference chip away at gene function. Nature Genetics, Vol 37, Issue 1038, pp 25-30.
42. Heid C A et al., Real Time Quantitative PCR. Genome Research, Vol 6, Issue 10, pp 986-994.
43. Maerken T V et al., Real Time qPCR as a tool for evaluating RNAi-mediated gene-silencing. Bio Rad Laboratories Inc., Vendor-submitted protocol.
44. Moffat Jason, Sabatini David, Building Mammalian Signalling Pathways with RNAi screens. Nature Reviews Molecular Cell Biology, Vol 7, pp 177-187.
45. Naqvi A R, Islam M D, Chaudhary N R, Rizwanul Q M, The Fascinating World of RNAi. International Journal of Biological Sciences, Vol 5, Issue 2, pp 97-117.
46. Ganguruju V K, Lin H, 2009. Biogenesis and Regulatory Features of miRNA, siRNA and piRNA Pathways. Nature Reviews Molecular Cell Biology, Vol 10, pp 116-125.
Web-Links
47. http://www.nobelprize.org/nobel_prizes/medicine/laureates/2006/illpres/2_central_dogma.html
48. http://www.biologyjunction.com/rna_interference_abstract.htm
49. http://news.bbc.co.uk/2/hi/health/5398844.stm
50. http://news.stanford.edu/pr/2006/pr-nobel-100206.html
51. http://news.sciencemag.org/sciencenow/2006/10/02-01.html
52. http://www.genome.gov/10000533
53. http://www.biotechniques.com/protocols/PCR/Real-time_PCR/Using-Real-time-qPCR-to-Evaluate-RNAi-mediated-Gene-Silencing/biotechniques-115517.html
54. http://appliedbiosystems.com/about/presskit/pdfs/pharma_discovery.pdf
55. http://rnai.org/
56. http://www.rnaiweb.com/RNAi/siRNA_Design/index.html
57. http://www.idosi.org/wjms/2(1)07/1.pdf
58. http://www.ncbi.nlm.nih.gov/pubmed/20686939
59. http://www.nature.com/mtna/journal/v1/n2/full/mtna20119a.html
Images
http://compbio.cs.toronto.edu/ligalign/desc.html
http://lifewithdoctordoubleyou.blogspot.in/2011/10/harvest-and-disappointment.html
http://www.chemguide.co.uk/organicprops/aminoacids/proteinstruct.html
http://www.vanderbilt.edu/exploration/text/index.php?action=view_section&id=1552&story_id=381&images=
http://strong-athlete.com/a-closer-look-at-insulin.html
http://www.labgrab.com/users/labgrab/blog/central-dogma-genetics-incomplete_id%3D904
http://en.wikipedia.org/wiki/Small_interfering_RNA
http://2009.igem.org/Team:Freiburg_bioware/Project/AGO
http://sandwalk.blogspot.in/2007_10_01_archive.html
https://www.qiagen.com/geneglobe/pathwayview.aspx?pathwayID=411
http://cmp.bsd.uchicago.edu/
http://blog.coursecracker.com/
http://www.genengnews.com/gen-news-highlights/gsk-taps-alnylam-s-rnai-technology-for-vaccine-production/81245900/
http://www.cogmed.com/references
http://www.ustr.gov/about-us/trade-toolbox/glossary-trade-terms
Videos and Animations
http://www.nature.com/nrg/multimedia/rnai/index.html
http://www.youtube.com/watch?feature=player_embedded&v=5Od7Dc9xTQA
http://www.youtube.com/watch?feature=player_embedded&v=Z3YU9C7xGrU
http://www.youtube.com/watch?feature=player_embedded&v=UE9gW4ryg2g
