The Central Dogma to RNA Interference RNA Interference RNA interference or RNAi is an evolutionarily conserved mechanism that uses short antisense RNAs that are generated by ‘dicing’ dsRNA precursors to target corresponding mRNA for cleavage [1]. In the last several years, RNA interference has emerged as an extremely effective and widely used method for interfering with the gene expression at the mRNA level. Short RNAs generated by the action of enzymes are involved in direct repression of genes with homology to those RNAs [2]. This process of RNAi can manifest as translational inhibition of the mRNA, destruction of the mRNA or transcriptional silencing of the promoter that directs expression of that mRNA [3]. Our knowledge of RNA interference has expanded dramatically in a short time since its discovery. Several types of small silencing RNA are now discovered - including small interfering RNAs (siRNAs), microRNAs (miRNAs) and PIWI-interacting RNA (piRNAs) [1]. RNAi gives a specific, potent and highly successful approach for loss-of function studies in virtually all eukaryotic organisms [37]. This website gives a review of data available on the RNA interference through text, pdfs and external links to provide the maximum user satisfaction on the information in the crisp and to-the-point format. This website highlights the phenomenon of RNAi and the wide range of applications it may possess. Please drop in your feedback/suggestions to help me improve with the site! Downloads | Glossary | References | Contact
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